BACKGROUND AND OBJECTIVE: Preeclampsia is one of the most prevalent diseases in pregnancy that include PROTEINuria and hypertension and can be associated with morbidity and mortality in mother and neonate. Endothelial cell dysfunction and inflammation are considered to have a crucial role in the pathophysiologic mechanism of preeclampsia. A systemic inflammatory response involves both the immune system and the clotting and fibrinolytic system. The aim of this study was to determine the association of fibrinogen and C-REACTIVE PROTEIN ((CRP)) with the severity of preeclampsia.METHODS: This cross-sectional study was performed on 44 normal pregnant women, 35 cases with mild preeclampsia and 19 cases with severe preeclampsia that referred to Shahid Yahyanejad hospital, Babol, Iran. All of patients were primigravida and single pregnancy, cases over the age of 15 and gestational age of 30 to 40 weeks. Patients didn’t receive betamethasone in last week. The diagnosis of preeclampsia is made whose blood pressure reaches 140/90 mmHg or greater with PROTEINuria (trace or greater in random urine samples). Blood sample were taken from all subjects to measure (CRP) and fibrinogen and send to single laboratory. Then the groups were compared.FINDINGS: The mean of (CRP) was significantly different in control (2.28±0.81) and mild preeclampsia group (4.91±5.99) (p=0.03), and there was not significant difference between control (2.28±0.81) and severe preeclampsia group (3.8±3.05). The mean of fibrinogen was not significantly different in control group (360.5±62.35) and mild preeclampsia (344.71±65.07) and severe preeclampsia groups (340.95±78.62).CONCLUSION: Results show that (CRP) increased in mild preeclampsia in comparison with control group but there was not significant difference between fibrinogen level in control group with mild and severe preeclampsia.

Background & Aim: One the most common problems of patients on maintenance hemodialysis is sleep disorders that depends on comorbidities, age, morning dialysis shift, blood pressure and female gender. In addition, nocturnal and daytime sleep abnormalities are accompanied with cardiovascular and infectious diseases. On the other hand, inflammatory processes play an important role in individuals with end-stage renal disease (ESRD) undergoing hemodialysis, and may affect the levels of additional inflammatory molecules, such as serum C-REACTIVE PROTEIN ((CRP)) which is accompanied with the aggravation of atherosclerosis, PROTEIN-dependent malnutrition and cardiovascular diseases.Therefore, the aim of this study was to evaluate the relationship between serum (CRP) level and the severity of sleep disorders in patients undergoing maintenance hemodialysis; no such study has been conducted in Iran or elsewhere.Patients and Methods: This analytical cross-sectional study was performed on 158 chronic hemodialysis patients (with hemodialysis duration of ³6 months) in Autumn 2005. The patients underwent hemodialysis trice a week (each time 3.5-4 hours). They completed Modified Post Sleep Inventory (PSI) questionnaire to assess sleep related disturbances in 3 forms of sleep: bedtime (PSI1), nocturnal sleep (PSI2) and awakening (PSI3). Simultaneously, a peripheral blood sample was taken for quantitive (CRP) level before initiating hemodialysis course. The data were collected, described and analyzed using SPSS V.13 software.Results: Statistically significant correlation was found between serum (CRP) level and PSImean (rs=0.191 and P=0.016).This correlation was more notable in females (rs=0.345 and P=0.002), patients with hemodialysis duration of 48 Months (rs=0.364 and P=0.001) and during nocturnal sleep (PSI2) (rs=0.249 and P=0.002). Whereas, no significant relationship was found between serum (CRP) level either with age categories or other forms of sleep disorder.Conclusion: The results of our study show that recommending anti-inflammatory treatment in patients on chronic hemodialysis for sleep disturbances is reasonable and rationale.

Introduction: Coronary artery disease (CAD) is among the most common, serious, chronic and life- threatening illnesses in the world. CAD represents a spectrum of conditions, with acute myocardial infarction at one end of it and silent ischemia at the other. There is growing evidence on importance of prognosis of C- reactive PROTEIN (CPR) in unstable angina and this PROTEIN is a maker of an adverse prognosis.Materials and Methods: In this cross- sectional research. We study all of the patients that admitted in the coronary care unit of the Shahid Rahimi hospital with unstable angina (n=32) and acute myocardial infarction (n=32), but exclude the patients with exclusion criteria.Complete clinical data and blood samples for laboratory measurements were collected on admission. A baseline ECG were obtained at entry and 12 hours later. A CFM echocardiogram was performed within initial 24 hours. Serum CPR levels were measured on admission and at time of hospital discharge. All patients were followed up for 14 days after discharge.Findings: Patients with MI showed a striking higher CPR during the duty period than with UA. The occurrence of cardiac events at 14 day follow up was related to CPR level at 48 hours and hospital discharge (p=0.02). CPR levels correlated inversely with ejection fraction (r=-0.44).Conclusion: Our data demonstrated that the CPR were significantly higher in patients with acute myocardial infraction than patients with unstable angina. Elevated levels of CPR were associated with cardiac vents out of hospital during a 14-day follow up.

Background & aim: Microbial super antigens have reported in blood and synovial fluid of rheumatoid arthritis patients. Whether or not, the presence of these super antigens could provoke the induction of serologic diagnostic factors, including (CRP) in patients? the purpose of this study was to production and purification one of the super antigen C of Staphylococcus aureus and it ʹ s effect on the induction of (CRP) in rat Methods: In this experimental study which was performed from December 2017 to September 2018 at the Baqiyatallah University of Medical Sciences. Twenty Wistar rats weighing 250 to 300 Grams were selected and divided into four groups of 5 members, included. By participated to workshops of animal laboratory control as well as intraperitoneal and intera-articular injection were carried out. Staphylococcus aureus super antigen C was purified by ultrafiltration (Amicon Ultra Centrifugal Filter Device) form 24 hours culture media and use specific antibody for immunoblotting confirmatory was carried out. The PROTEIN concentration was measured. 50 micrograms of toxin were injected intraperitoneal and intra-articular into separate rat groups. In time course blood collection and (CRP) was tested. The results were analyzed. Results: The results showed that 50 to 100 μ g of toxin intra-articular and intraperitoneal after 20 days inducted (CRP) production at 0. 7 mg. After 40 days, this increased to 2. 2 mg/lit and after 50 days it reached to 4. 5 mg/lit. ANOVA analysis was shown the difference between the groups and with a significant level for groups was P≤ 0. 001 and for the intervals of the effect of super antigen was P≤ 0. 075, respectively. Conclusion: The results indicate that the presence and survival of staphylococcal super antigen C in the body of wistar rats induced the production of (CRP) factor. Although this finding is an introduction to further research, it is likely to provide new ways to prevent and control inflammatory diseases, including rheumatoid arthritis.